Ko te whāinga o tēnei rangahau he whakarato raraunga mōngārara patu pepekete ātete mō te whakatau kaupapa mō ngā kaupapa whakahaere ātete i Togo.
I aromatawaihia te tūnga ngoikore o Anopheles gambiae (SL) ki ngā patu pepeke e whakamahia ana i roto i te hauora tūmatanui mā te whakamahi i te kawa whakamātautau in vitro a te WHO. I whakahaerehia ngā whakamātautau koiora mō te ātete ki te pyrethroid i runga anō i ngā kawa whakamātautau pounamu a te CDC. I whakamatautauria ngā mahi whākōkī tango paitini mā te whakamahi i ngā synergists piperonyl butoxide, SSS-phosphorothioate, me te ethacrine. Te tautuhi momo-motuhake me te ira-ira o te whakarerekētanga kdr i roto i te Anopheles gambiae SL mā te whakamahi i te hangarau PCR.
I whakaatuhia e ngā taupori ā-rohe o Anopheles gambiae sl te tino pāngia e te pirimiphos-methyl i Lomé, Kowie, Aniye me Kpeletutu. E 90% te mate i Bayda, e tohu ana i te ātete pea ki te pirimiphos-methyl. I tuhia te ātete ki te DDT, benzodicarb me te propoxur i ngā wāhi katoa. I tuhia ngā taumata teitei o te ātete ki ngā pyrethroids, me ngā oxidases, esterases me te glutathione-s-transferases hei whākōkī whakakore paitini e kawenga ana mō te ātete, e ai ki ngā whakamātautau synergistic. Ko ngā momo matua i kitea ko Anopheles gambiae (ss) me Anopheles cruzi. I kitea ngā auau teitei o kdr L1014F me ngā auau iti o kdr L1014S i ngā wāhi katoa.
E whakaatu ana tēnei rangahau i te hiahia mō ētahi atu taputapu hei whakapakari i ngā wawaotanga whakahaere malaria e ahu mai ana i ngā patu pepeke (IRS me te LLIN).
He wāhanga nui te whakamahinga o ngā patu pepeke i roto i ngā kaupapa whakahaere i ngā mate malaria i Āwherika [1]. Heoi, ko te putanga mai o te ātete ki ngā momo matua o ngā patu pepeke e whakamahia ana i roto i te maimoatanga kupenga moenga me te rehu toenga o roto (IRS) me whakaaro anō tātou ki te whakamahinga o ēnei hua me te whakahaere i te ātete ki ngā mate [2]. Kua pūrongohia te putanga mai o te ātete rongoā i roto i ngā whenua maha o Āwherika ki te Hauāuru tae atu ki a Benin, Burkina Faso, Mali [3, 4, 5] me Togo rawa atu [6, 7]. Kua whakaatuhia e ngā rangahau tata nei ko te whakamahinga o ngā synergists me ngā huinga o ngā patu pepeke ka whakanui ake i te ngoikore o ngā mate malaria i roto i ngā rohe he nui te ātete ki ngā pyrethroids [8, 9]. Hei pupuri i te pumau o ngā rautaki whakahaere, me whakaaro ki te whakaurunga pūnaha o te whakahaere ātete ki roto i tētahi kaupapa here whakahaere mate [2]. Me tautoko e tētahi whenua te whakatinanatanga o ngā kaupapa whakahaere ātete mā te kimi ātete [10]. E ai ki ngā taunakitanga a te World Health Organization (WHO) [10], ko te whakahaere ātete e uru ana ki te whakatinanatanga o tētahi huarahi e toru ngā taahiraa tae atu ki (1) te aromatawai i te tūnga o te ngoikore o ngā kaipatu pepeke ki ngā pepeke, (2) te tautuhi i te kaha o te ātete, me (3) te aromatawai i ngā tikanga ā-tinana, me te aro nui ki te whai huatanga o te piperonyl butoxide (PBO) synergist. I Togo, ko te taahiraa tuatahi, ko te aromatawai i te tūnga o te ngoikore o ngā kaipatu pepeke ki ngā pepeke malaria, ka mahia i ia 2-3 tau i ngā wāhi tiaki o te National Malaria Control Programme (NMCP). Kāore anō kia rangahaua whānuitia te kaha ātete me te whai huatanga o ngā taahiraa whakamutunga e rua (arā, ngā potentiator piperonyl butoxide (PBO), S,S,S-tributyl trisulfate phosphate (DEF), me te waikawa ethacrynic (EA)).
Ko te whāinga o tēnei rangahau he aro atu ki ēnei āhuatanga e toru, me te whakarato i ngā raraunga pono ki te NMCP hei whakatau kaupapa mō te whakahaere ātete i Togo.
I whakahaerehia tēnei rangahau mai i Hune ki Hepetema 2021 i ētahi wāhi tiaki NMCP i roto i ngā rohe hauora e toru i te tonga o Togo (Pikitia 1). E rima ngā wāhi aroturuki NMCP i tīpakohia hei aroturuki i runga i ō rātou rohe whenua (ngā rohe hauora rerekē) me ngā āhuatanga taiao (te nui o ngā kaikawe, ngā wāhi whakaputa uri torongū tūturu): Lomé, Bayda, Kowie, Anyère me Kpeletoutou (Ripanga 1).
E whakaatu ana tēnei rangahau he ātete ngā taupori waeroa Anopheles gambiae o te tonga o Togo ki ētahi patu pepeke nui mō te hauora tūmatanui, engari ko te pirimiphos-methyl. I kitea he nui ngā taumata ātete pyrethroid i te wāhi rangahau, e pā ana pea ki ngā whākōkī whakakore paitini (ngā oxidases, ngā esterases me ngā glutathione-s-transferases). I kitea te whakarerekētanga kdr L1014F i roto i ngā momo tuahine e rua, arā, ko Anopheles gambiae ss me Anopheles kruzi me ngā auau allele rerekē engari teitei (>0.50), engari ko te whakarerekētanga kdr L1014S i puta i te auau tino iti, ā, i kitea anake i roto i ngā waeroa Anopheles cruzi. Nā ngā hononga tahi PBO me EA i whakahoki te ngoikore ki ngā pyrethroids me ngā organochlorines, i ngā wāhi katoa, i te mea i whakanui ake a DEF i te ngoikore ki ngā carbamates me ngā organophosphates i ngā wāhi katoa engari ko Anye. Tērā pea ka āwhina ēnei raraunga i te Kaupapa Whakahaere Malaria ā-Motu o Togo ki te whakawhanake i ngā rautaki whakahaere mate urutā whai hua ake.
Wā tuku: Hakihea-23-2024